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Step 1
Preheat oven to 275°.
Step 2
Heat butter or vegetable oil in a large skillet over medium-high heat. Brown brisket 5-8 minutes per side.
Step 3
Place brisket on rack in roasting pan. Add 2 Tablespoons water to pan. Cover brisket with sliced onion and garlic. Cover pan tightly with aluminum foil.
Step 4
Bake for 1 hour 20 minutes per pound, or until fork tender. A 5 pound brisket will take approximately 6 hours.