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Gather the ingredients. The Spruce / Diana Rattray Shape the meat into four 6-ounce burgers. Make each patty a little larger than the bun since it will shrink while cooking. Add an indentation in the center of each burger with your thumb. This will prevent swelling in the center as they cook. Sprinkle lightly with kosher salt and freshly ground black pepper. The Spruce / Diana Rattray Heat the unsalted butter in a heavy skillet over medium to medium-low heat. Add one or two burgers to the skillet and cook for about 3 to 4 minutes on each side, waiting until the bottom of the burger releases easily from the pan before flipping. The Spruce / Diana Rattray Continue to cook the burgers, flipping occasionally, until they register 160 F on an instant-read thermometer. Repeat with the remaining burgers. The Spruce / Diana Rattray Assemble the burgers in the buns with your choice of sauce and toppings. The Spruce / Diana Rattray Enjoy your bison burgers! The Spruce / Diana Rattray