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Cook pasta according to package directions.
Drain pasta well.
Brown ground beef with onion, garlic and Italian seasoning.
Start preheating oven to 350F degrees
Drain excess grease from ground beef.
In a large bowl, mix together pizza sauce and water.
Add in cooked pasta, 1 1/2 cups mozarella cheese, cooked ground beef and 20 slices of pepperoni (that have been sliced in half).
Spray 8 x 8 baking dish with nonstick cooking spray.
Pour in pasta mixture.
Sprinkle with remaining 1/2 cup of mozzarella cheese.
Place remaining pepperoni slices on top.
Cover with aluminum foil.
Bake at 350 for 20 minutes.
Remove aluminum foil and bake for another 5-10 minutes (until cheese is melted).