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Make the rub by mixing all of the rub ingredients in a bowl or jar.
If needed, cut the brisket into 2 (or more) pieces so it will fit into the Instant Pot. Rub the seasoning mixture all over the brisket.
Press the "Saute" button on the Instant Pot and add in the ghee. Mix the ghee around as the pot heats up to coat the bottom of the pot.
Add the brisket to the Instant Pot and sear each side for about 3-4 minutes. You want a quick sear to brown all sides of the brisket. You may need to work in batches.
Once all of the brisket has seared, Press the "keep warm/cancel" button. Remove from the Instant Pot. Pour the beef broth in and deglaze the pot, scraping the bottom of the pan to remove any bits.
Add the brisket back into the Instant Pot.
Secure the lid on the Instant Pot and close the pressure valve. Press "manual" button (or "pressure cook" button) and set the time for 75 minutes at high pressure. Once the time is up, let the pressure naturally release for 15 minutes and then carefully manually release the remaining pressure.
While the brisket is cooking, make the BBQ sauce by combining the sauce ingredients in a bowl or jar and mixing well. Cover and refrigerate.
When the brisket is finished, remove and place it on a cutting board. Wrap the brisket in foil to rest for at least 10 minutes (or longer). You can also wrap it with parchment paper plus a towel around the parchment paper if you don't want to use foil.
If you want warm BBQ sauce, remove the broth from the instant pot (reserve for later - for dipping or pouring over the brisket slices). Press the "Saute" button on the Instant pot and pour in the BBQ sauce. Cook the sauce, stirring occasionally, for a few minutes to warm it up. Press the "keep warm/cancel" button.
Slice the brisket against the grain for serving. Serve topped with BBQ sauce. You could also add the pieces back into the Instant Pot to coat with the sauce before serving.