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Step 1
Preheat the oven to 425°F. Whisk together the glaze ingredients in a small bowl and set aside.
Step 2
Take the pork tenderloin out of the refrigerator 30 minutes before cooking. Season the tenderloin on both sides with salt, pepper and the chili powders.
Step 3
Heat oil in a cast iron skillet. Add the pork tenderloin to the skillet and sear on all sides until a crust has formed (about 10 minutes). Remove from heat and brush both sides with a little bit of the glaze.
Step 4
Place the skillet in the oven and roast the tenderloin until an instant-read thermometer inserted into the center of the tenderloin reads 140°F (about 12 minutes).
Step 5
Remove the roast and place it on a cutting board and top with more glaze and cover with foil. Let it rest 10 minutes. Cut 1/2" slices, top with more glaze and serve.