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Step 1
Preheat the oven to 425 degrees F. Line a large rimmed baking sheet with parchment paper.
Step 2
Make the seasoning: Whisk together the chili powder, smoked paprika, onion powder, garlic powder, cumin, sugar, and salt in a small bowl. Set aside.
Step 3
Make the quesadillas: Heat the oil in large nonstick skillet over medium-high heat. Add the turkey and cook, breaking up the meat, until the turkey is no longer pink and most of the liquid has evaporated, 4 to 5 minutes. Stir in the fajita seasoning, sour cream, bell peppers, and onions and cook on medium-high heat, stirring occasionally, until the onions are tender, 4 to 5 minutes.
Step 4
Assemble and bake the quesadillas: Spread a thin layer of mayonnaise onto 2 of the tortillas and arrange them mayo-side down on the prepared baking sheet (this will help the tortillas brown), then sprinkle with half of the cheese edge-to-edge. Top with the filling then repeat sprinkling with the remaining cheese. Cover each quesadilla with 1 of the remaining tortillas and spread a thin layer of mayonnaise on top. Place another piece of parchment paper directly on top of the quesadillas followed by another large baking sheet to weigh them down.
Step 5
Bake 15 to 20 minutes, until the cheese is melted and the tortillas are crispy. Cut into wedges and serve warm.