Step 1

Preheat the oven to 450°F.

Step 2

In a small bowl, mix garlic powder, chili powder, salt, black pepper and cayenne.

Step 3

Sprinkle evenly over both sides of tilapia.

Step 4

Coat a baking sheet with 1 tablespoon of the oil.

Step 5

Arrange tilapia in a single layer on the baking sheet; drizzle with the remaining tablespoon of oil.

Step 6

Bake until golden brown and flesh begins to flake, 7 to 9 minutes. Serve with lime wedges on the side.