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Preheat the oven to 350°F. Spray a 9×13" baking pan or dish with non-stick cooking spray; set aside.
In a large mixing bowl, whisk the eggs and water together until well combined.
Add the stuffing mix, ground beef, and 1/4 cup of ketchup. Use your hands to mix the ingredients together until well combined.
Transfer the meat to the baking dish and shape the meat into a loaf.
Brush the meatloaf evenly with the remaining 1/4 cup of ketchup.
Bake at 350°F for 55 minutes. Cool for 10 minutes then slice and serve.