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Step 1
In a medium bowl, combine Spice Mixture ingredients and rub over trimmed brisket. Place brisket in a large ziplock bag or other tightly covered container and refrigerate 8 hours or overnight.
Step 2
Pour one cup of water in the Instant Pot and insert the steam rack. Stack the brisket pieces on the rack, fat side up.
Step 3
Secure the lid, making sure the vent is closed.
Step 4
Using the display panel select the MANUAL or PRESSURE COOK function*. Use the +/- keys and program the Instant Pot for 75 minutes.
Step 5
When the time is up, let the pressure naturally release for 15 minutes, then quick-release the remaining pressure.
Step 6
Carefully remove the meat from the pot to a foil-covered baking sheet and brush with BBQ sauce.
Step 7
Set the brisket under the broiler for 4-5 minutes until caramelized and bubbly.
Step 8
Slice meat against the grain and serve.