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Step 1
Preheat the oven to 375°F. Line a baking sheet with aluminum foil or parchment paper and spray with non-stick cooking spray. Place tilapia on the pan or a cutting board to trim.
Step 2
In a shallow bowl, stir together cumin, salt, garlic powder, and cayenne.
Step 3
Dredge the tilapia in the spice mixture until well coated on each side. Place on baking sheet.
Step 4
Drizzle tilapia with olive oil and dot with butter. Cook 20 to 25 minutes, or until flakes easily with a fork and is no longer translucent in the center. A digital thermometer should read 140°F at the thickest part. To brown the edges, broil an additional 2 to 3 minutes.
Step 5
Allow to rest for a few minutes before serving. Squeeze fresh lime or lemon on top if desired.