Gather the ingredients.Heat oven to 400 F (204 C)To a large mixing bowl, add ground beef, eggs, applesauce, breadcrumbs, onion, green pepper, Worcestershire sauce, and 1/2 cup ketchup.Use your hands to thoroughly blend the mixture. You can use disposable gloves if you like.Add a small amount of milk or water, if necessary, to moisten the mixture.Use a large spatula to scoop the meat mixture into a 9x5x3-inch loaf pan. Press down and smooth the top.Bake in heated oven for 30 minutes. Carefully remove pan and pour off excess fat.Spread remaining 1/2 cup ketchup over the top of the loaf.Return to oven and bake for an additional 30 minutes.Serve and enjoy!TipsKeep a batch or two of homemade gluten-free breadcrumbs in the freezer, and you'll be set to make gluten-free meatloaf anytime you want. Easy and convenient. When purchasing sauces for this recipe, be sure to check labels as some brands include gluten. Annie's Naturals Organic Ketchup is a delicious gluten-free ketchup option. Always make sure your work surfaces, utensils, pans, and tools are free of gluten. Always read product labels. Manufacturers can change product formulations without notice. When in doubt, do not buy or use a product before contacting the manufacturer for verification that the product is free of gluten.Recipe VariationsTo make meatloaf gluten-free, simply swap regular breadcrumbs for gluten-free breadcrumbs or cracker crumbs. Also, confirm the ketchup and Worcestershire sauce used in this recipe are ones that do not contain gluten. To lighten up this recipe, swap ground turkey in place of ground beef. To add a little heat to your meatloaf, add 1/4 teaspoon of red pepper flakes.