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Preheat oven to 350 degrees F. Gently combine all ingredients except ketchup in a large bowl. Transfer to a greased loaf pan.
Bake (uncovered) for about 60 minutes, or until meatloaf reaches an internal temperature of 160°F and juices run clear. Tilt the pan to drain off the grease; spread ketchup on top, and return to the oven for 10 more minutes.
Let stand 5 minutes before slicing.