Step 1

Combine salt, chili powder, and lime zest and spread out a small plate.

Step 2

Wipe the rim of a highball glass with a wedge of lime. Dip into the chili-lime salt to coat rim.

Step 3

In a cocktail shaker filled with ice, combine the mezcal, grapefruit juice, and simple syrup and shake about 15 seconds.

Step 4

Pour into a salt-rimmed glass and top off with club soda and a few ice cubes. Garnish with mint and grapefruit wedges.