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Step 1
Place 1/4 cup all-purpose flour, 1/2 teaspoon garlic powder, and 1/2 teaspoon onion powder in a shallow bowl or plate and whisk to combine. Place 1/2 cup panko breadcrumbs and 2 ounces Parmesan cheese to a second shallow bowl or plate and whisk to combine. Add 2 large eggs to a third shallow bowl or plate and whisk to combine.
Step 2
Slice 2 boneless, skinless chicken breasts in half horizontally (also known as butterflying). Season all over with 3/4 teaspoon kosher salt and 1/4 teaspoon black pepper.
Step 3
Working with one piece of chicken at a time, coat the chicken in the flour mixture, then dip in the egg, letting any excess drip off. Coat in the panko-Parmesan crumbs. Place on a baking sheet or plate in a single layer.
Step 4
Heat an air fryer to 400°F. Place 2 breaded chicken pieces in a single layer in the air fryer basket, making sure they do not overlap. Coat with cooking spray. Air fry until golden and crisp, 5 to 6 minutes.
Step 5
Top each piece of chicken with a slice of mozzarella cheese, and secure each piece of cheese with 2 toothpicks. Air fry until the chicken is golden brown, an instant-read thermometer inserted into the center registers at least 165°F, and the cheese melts, 1 to 2 minutes more.
Step 6
Transfer to a plate and cover loosely with aluminum foil. Repeat air frying the remaining chicken and cheese. When the second batch is almost ready, warm 1 cup marinara sauce on the stovetop over medium heat or in the microwave until warm.
Step 7
To serve, remove the toothpicks, divide the marinara sauce evenly among serving plates, and nestle each serving of chicken Parmesan on top. Garnish with fresh basil leaves, if desired.