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Preheat oven to 400 degrees F. Spray a baking sheet with nonstick spray.
In a shallow dish, combine: flour, breadcrumbs, chili powder, smoked paprika, red pepper flakes, garlic powder, onion powder, and salt. Toss to thoroughly combine.
In a separate bowl, combine the hot sauce with the beaten egg.
Dip each piece of chicken into the hot sauce mix and then into the breadcrumb mix. Firmly press the breading onto each piece and then place onto the baking sheet.
Using nonstick cooking spray, give the nuggets a generous sweep of the spray. I used olive oil. This will help to crisp them as they bake.
Bake for 8 minutes. Remove from the oven to flip and allow to bake 8-10 additional minutes. Time will be dependent on how large your nuggets are, so its best to check at 5 minutes. Bake until no longer pink or internal temperature should read 165 degrees F.
Serve with your favorite sauce!