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Lightly spray a baking sheet with cooking spray or line with a silpat. Preheat the oven to 400°F.
Melt the butter in a small bowl. Add the Parmesan, garlic powder, oregano, parsley, and salt. Mix together and set aside.
Open the can of biscuits. Cut each of the 8 pieces of dough in half so that you have 16 pieces of dough. Roll each piece into a rope about 6 inches long and 1/2 inch thick.
Tie each rope into a knot. Place them on the baking sheet making sure to tuck the end of the rope under the knot.
Brush the tops of the dough knot with half of the butter mixture. Bake for 9-12 minutes or until golden brown.
Remove knots from the oven and brush with the remaining butter mixture. Serve warm.