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Step 1
In a large bowl, whisk together flour, garlic powder, onion powder, chili powder, and cumin. Whisk to combine.
Step 2
Season tilapia filets generously with salt and pepper, then dip each in flour mixture, shaking off any excess flour. Place on a clean plate or baking sheet.
Step 3
In a large, nonstick skillet over medium heat, heat oil. Add 2 filets and cook 3 to 4 minutes per side, until crust is golden and fish flakes easily with a fork. Repeat with remaining filets.
Step 4
Serve immediately with cilantro and lime wedges.