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Preheat oven to 350 degrees F.
In a large bowl combine ground beef, pork rinds, egg, Worcestershire sauce, onion powder, salt, and garlic powder. Mix ingredients until fully combined.
Press ½ of the ground beef mixture into the bottom of a parchment paper lined loaf pan. Make a slight indentation in the center of the ground beef leaving a 1 inch edge.
Place cubed American cheese into indentation and the cover with the remaining ground beef mixture pressing it into the bottom half so the meatloaf is sealed.
Bake for 60-70 minutes.
While the meatloaf bakes whisk all of the Big Mac sauce ingredients together in a bowl. Set aside.
When done baking remove the meatloaf from the oven and let rest for 10 minutes.
Remove the meatloaf from the pan and then top with Big Mac sauce.