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Preheat the oven to 300 degrees.
Slice the bread into 1-inch cubes to create 4 cups.
Place in a food processor and grind into finer crumbs. (See notes for food processor alternatives)
Arrange in a single, even layer on 1-2 baking sheets.
Bake for 10 minutes, toss, bake for 5 more minutes.
If desired, place back in the food process and grind it into finer crumbs.
Add Italian seasonings after baking if desired, 1.5 teaspoons of seasoning for every cup. See notes for seasoning recipe.
Store in an airtight container at room temperature for up to a month, or freeze for up to 3 months.