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Cook spaghetti squash - Cook spaghetti squash *see note Scoop out seeds and shred into noodles with a fork.
Cook Turkey - Heat oven to 350°F. Cook ground turkey in a nonstick skillet over medium heat, breaking it up with a spatula and cooking until no pink remains (roughly 7 minutes). Cool slightly.
Combine - In a large bowl, stir together all ingredients, reserving 3/4 cup of cheese. Scrape into a deep 9X13 inch casserole dish and sprinkle with the reserved 3/4 cup of cheese.
Bake - Cover and bake for 45 minutes. Bake uncovered for another 15 minutes, until casserole is cooked through and bubbling.
Serve - Allow casserole to rest for at least 10 minutes before serving. The longer it sits the more it sets up.