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In a small bowl, mix the salt, pepper, garlic powder and oregano together.
Spray the chicken breasts on the presentation side (smooth side) with cooking spray of choice. I use avocado oil spray.
Sprinkle some of the seasoning blend on each chicken breast, and use hands to pat and help the seasoning stick.
Place the chicken breast, seasoned side down, in the air fryer.
Spray the bare side, which is now facing up, and sprinkle on the remaining seasoning.
Cook for 10 minutes on 360 degrees.
Flip over (tongs are extremely helpful), and cook until internal temperature reaches at least 165, about another 8 to 12 minutes on 360 depending on the size of your chicken breasts. (Mine were about 7.75 ounces each, and 10 minutes on the 2nd side was perfect.👌🏻That's 20 minutes total. See cook time notes section below.)
Remove the basket from the air fryer, and allow the chicken to rest for about 5 minutes before cutting into it. This lets the juices redistribute and helps the chicken be juicier.