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Step 1
Preheat oven to 400°F or 200°C.
Step 2
Melt butter in a skillet on the stovetop or in the microwave.
Step 3
Pat the tilapia fillets dry with paper towels and add them to a 9 by 13 baking dish.
Step 4
Season both sides of the fillets with ¼ teaspoon of salt, ⅛ teaspoon of black pepper, the onion powder, paprika, and crushed pepper flakes.
Step 5
In a small bowl, whisk together the melted butter, minced garlic, and remaining salt and pepper.
Step 6
Pour the butter mixture over the seasoned tilapia ensuring that the garlic butter evenly coats the tilapia.
Step 7
Place into the preheated oven and bake for 10-12 minutes until the fish flakes easily with a fork.
Step 8
For a brown color on the fish, turn on the broiler and broil for 1-2 minutes.
Step 9
Garnish with fresh minced parsley and/or dill and serve warm with lemon wedges.