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Step 1
Preheat the oven to 350 degrees F (175 degrees C). Lightly grease a 9x13 inch baking dish.
Step 2
Season the tilapia fillets with salt, pepper and Cajun seasoning on both sides. Arrange the seasoned fillets in a single layer in the baking dish. Place a layer of lemon slices over the fish fillets. I usually use about 2 slices on each piece so that it covers most of the surface of the fish.
Step 3
Bake uncovered for 15 to 20 minutes in the preheated oven, or until fish flakes easily with a fork.
Step 4
While the fish is baking, mix together the mayonnaise, sour cream, garlic powder, lemon juice and dill in a small bowl. Serve with tilapia.